SrasV1, France, Analysis, bibRecord, 000401

Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome

Identifieur interne : 000401 ( France/Analysis ); précédent : 000400; suivant : 000402

Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome

Auteurs : This Kuiken [Pays-Bas] ; Ron A. M. Fouchier [Pays-Bas] ; Martin Schutten [Pays-Bas] ; Guus F. Rimmelzwaan [Pays-Bas] ; Geert Van Amerongen [Pays-Bas] ; Debby Van Riel [Pays-Bas] ; Jon D. Laman [Pays-Bas] ; Ton De Jong [Pays-Bas] ; Gerard Van Doornum [Pays-Bas] ; Wilina Lim [République populaire de Chine] ; AI EE LING [Singapour] ; Paul K. S. Chan [Hong Kong] ; John S. Tam [Hong Kong] ; Maria C. Zambon [Royaume-Uni] ; Robin Gopal [Royaume-Uni] ; Christian Drosten [Allemagne] ; Sylvie Van Der Werf [France] ; Nicolas Escriou [France] ; Jean-Claude Manuguerra [France] ; Klaus Stöhr [Suisse] ; J. S. Malik Peiris [Hong Kong] ; Albert D. M. E. Osterhaus [Pays-Bas]

Source :

Lancet : (British edition) [ 0140-6736 ] ; 2003.

RBID : Pascal:03-0484722

Descripteurs français

KwdFr :
- Alvéoles pulmonaires (anatomopathologie), Alvéoles pulmonaires (virologie), Animaux, Chine (épidémiologie), Flambées de maladies, Humains, Macaca fascicularis, Maladies transmissibles émergentes (virologie), Maladies transmissibles émergentes (épidémiologie), Modèles animaux de maladie humaine, Santé mondiale, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Virus du SRAS (isolement et purification), Virus du SRAS (pathogénicité).
MESH :
- anatomopathologie : Alvéoles pulmonaires, Syndrome respiratoire aigu sévère.
- isolement et purification : Virus du SRAS.
- pathogénicité : Virus du SRAS.
- virologie : Alvéoles pulmonaires, Maladies transmissibles émergentes, Syndrome respiratoire aigu sévère.
- épidémiologie : Chine, Maladies transmissibles émergentes, Syndrome respiratoire aigu sévère.
Pascal (Inist)
- Animaux, Coronavirus, Flambées de maladies, Homme, Humains, Macaca fascicularis, Modèles animaux de maladie humaine, Santé mondiale, Syndrome respiratoire aigu sévère.
Wicri :
- geographic : République populaire de Chine.
- topic : Homme.

English descriptors

KwdEn :
- Animals, China (epidemiology), Communicable Diseases, Emerging (epidemiology), Communicable Diseases, Emerging (virology), Coronavirus, Disease Models, Animal, Disease Outbreaks, Global Health, Human, Humans, Macaca fascicularis, Pulmonary Alveoli (pathology), Pulmonary Alveoli (virology), SARS Virus (isolation & purification), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome.
MESH :
- geographic , epidemiology : China.
- epidemiology : Communicable Diseases, Emerging, Severe Acute Respiratory Syndrome.
- isolation & purification : SARS Virus.
- pathogenicity : SARS Virus.
- pathology : Pulmonary Alveoli, Severe Acute Respiratory Syndrome.
- virology : Communicable Diseases, Emerging, Pulmonary Alveoli, Severe Acute Respiratory Syndrome.
- Animals, Disease Models, Animal, Disease Outbreaks, Global Health, Humans, Macaca fascicularis.

Abstract

Background The worldwide outbreak of severe acute respiratory syndrome (SARS) is associated with a newly discovered coronavirus, SARS-associated coronavirus (SARS-CoV). We did clinical and experimental studies to assess the role of this virus in the cause of SARS. Methods We tested clinical and postmortem samples from 436 SARS patients in six countries for infection with SARS-CoV, human metapneumovirus, and other respiratory pathogens. We infected four cynomolgus macaques (Macaca fascicularis) with SARS-CoV in an attempt to replicate SARS and did necropsies on day 6 after infection. Findings SARS-CoV infection was diagnosed in 329 (75%) of 436 patients fitting the case definition of SARS; human metapneumovirus was diagnosed in 41 (12%) of 335, and other respiratory pathogens were diagnosed only sporadically. SARS-CoV was, therefore, the most likely causal agent of SARS. The four SARS-CoV-infected macaques excreted SARS-CoV from nose, mouth, and pharynx from 2 days after infection. Three of four macaques developed diffuse alveolar damage, similar to that in SARS patients, and characterised by epithelial necrosis, serosanguineous exudate, formation of hyaline membranes, type 2 pneumocyte hyperplasia, and the presence of syncytia. SARS-CoV was detected in pneumonic areas by virus isolation and RT-PCR, and was localised to alveolar epithelial cells and syncytia by immunohistochemistry and transmission electron microscopy. Interpretation Replication in SARS-CoV-infected macaques of pneumonia similar to that in human beings with SARS, combined with the high prevalence of SARS-CoV infection in SARS patients, fulfill the criteria required to prove that SARS-CoV is the primary cause of SARS.

Url:

Affiliations:

Links to Exploration step

Pascal:03-0484722

Le document en format XML

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<author><name sortKey="Stohr, Klaus" sort="Stohr, Klaus" uniqKey="Stohr K" first="Klaus" last="Stöhr">Klaus Stöhr</name>
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<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
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<author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>3000 DR Rotterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schutten, Martin" sort="Schutten, Martin" uniqKey="Schutten M" first="Martin" last="Schutten">Martin Schutten</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
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<wicri:noRegion>3000 DR Rotterdam</wicri:noRegion>
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<author><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>22 aut.</sZ>
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<wicri:noRegion>3000 DR Rotterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Riel, Debby" sort="Van Riel, Debby" uniqKey="Van Riel D" first="Debby" last="Van Riel">Debby Van Riel</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Immunology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>3000 DR Rotterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Laman, Jon D" sort="Laman, Jon D" uniqKey="Laman J" first="Jon D." last="Laman">Jon D. Laman</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Immunology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>3000 DR Rotterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Jong, Ton" sort="De Jong, Ton" uniqKey="De Jong T" first="Ton" last="De Jong">Ton De Jong</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Pathology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>3000 DR Rotterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Doornum, Gerard" sort="Van Doornum, Gerard" uniqKey="Van Doornum G" first="Gerard" last="Van Doornum">Gerard Van Doornum</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>3000 DR Rotterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lim, Wilina" sort="Lim, Wilina" uniqKey="Lim W" first="Wilina" last="Lim">Wilina Lim</name>
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<s2>Kowloon</s2>
<s3>CHN</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
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<wicri:noRegion>Kowloon</wicri:noRegion>
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</author>
<author><name sortKey="Ai Ee Ling" sort="Ai Ee Ling" uniqKey="Ai Ee Ling" last="Ai Ee Ling">AI EE LING</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pathology, Singapore General Hospital</s1>
<s3>SGP</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Singapour</country>
<wicri:noRegion>Department of Pathology, Singapore General Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name>
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<s3>HKG</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
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<wicri:noRegion>Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion>
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<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
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<s3>HKG</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital</wicri:noRegion>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zambon, Maria C" sort="Zambon, Maria C" uniqKey="Zambon M" first="Maria C." last="Zambon">Maria C. Zambon</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Enteric Respiratory and Neurological Virus Laboratory, Health Protection Agency</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gopal, Robin" sort="Gopal, Robin" uniqKey="Gopal R" first="Robin" last="Gopal">Robin Gopal</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Enteric Respiratory and Neurological Virus Laboratory, Health Protection Agency</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Virology, Bernhard-Nocht Institute for Tropical Medicine</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Unité de Génétique Moléculaire des Virus Respiratoires, Institut Pasteur</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Escriou, Nicolas" sort="Escriou, Nicolas" uniqKey="Escriou N" first="Nicolas" last="Escriou">Nicolas Escriou</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Unité de Génétique Moléculaire des Virus Respiratoires, Institut Pasteur</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Manuguerra, Jean Claude" sort="Manuguerra, Jean Claude" uniqKey="Manuguerra J" first="Jean-Claude" last="Manuguerra">Jean-Claude Manuguerra</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Unité de Génétique Moléculaire des Virus Respiratoires, Institut Pasteur</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stohr, Klaus" sort="Stohr, Klaus" uniqKey="Stohr K" first="Klaus" last="Stöhr">Klaus Stöhr</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>SARS Aetiology Study Group, WHO</s1>
<s2>Geneva</s2>
<s3>CHE</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>Geneva</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Microbiology and Medicine, Queen Mary Hospital, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Microbiology and Medicine, Queen Mary Hospital, University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Virology, Erasmus Medical Centre, PO Box 1738</s1>
<s2>3000 DR Rotterdam</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>3000 DR Rotterdam</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Lancet : (British edition)</title>
<title level="j" type="abbreviated">Lancet : (Br. ed.)</title>
<idno type="ISSN">0140-6736</idno>
<imprint><date when="2003">2003</date>
</imprint>
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<seriesStmt><title level="j" type="main">Lancet : (British edition)</title>
<title level="j" type="abbreviated">Lancet : (Br. ed.)</title>
<idno type="ISSN">0140-6736</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>China (epidemiology)</term>
<term>Communicable Diseases, Emerging (epidemiology)</term>
<term>Communicable Diseases, Emerging (virology)</term>
<term>Coronavirus</term>
<term>Disease Models, Animal</term>
<term>Disease Outbreaks</term>
<term>Global Health</term>
<term>Human</term>
<term>Humans</term>
<term>Macaca fascicularis</term>
<term>Pulmonary Alveoli (pathology)</term>
<term>Pulmonary Alveoli (virology)</term>
<term>SARS Virus (isolation & purification)</term>
<term>SARS Virus (pathogenicity)</term>
<term>Severe Acute Respiratory Syndrome (epidemiology)</term>
<term>Severe Acute Respiratory Syndrome (pathology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Severe acute respiratory syndrome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alvéoles pulmonaires (anatomopathologie)</term>
<term>Alvéoles pulmonaires (virologie)</term>
<term>Animaux</term>
<term>Chine (épidémiologie)</term>
<term>Flambées de maladies</term>
<term>Humains</term>
<term>Macaca fascicularis</term>
<term>Maladies transmissibles émergentes (virologie)</term>
<term>Maladies transmissibles émergentes (épidémiologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Santé mondiale</term>
<term>Syndrome respiratoire aigu sévère (anatomopathologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Syndrome respiratoire aigu sévère (épidémiologie)</term>
<term>Virus du SRAS (isolement et purification)</term>
<term>Virus du SRAS (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Alvéoles pulmonaires</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Communicable Diseases, Emerging</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Pulmonary Alveoli</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Alvéoles pulmonaires</term>
<term>Maladies transmissibles émergentes</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Communicable Diseases, Emerging</term>
<term>Pulmonary Alveoli</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term>
<term>Maladies transmissibles émergentes</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Disease Outbreaks</term>
<term>Global Health</term>
<term>Humans</term>
<term>Macaca fascicularis</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term>
<term>Coronavirus</term>
<term>Flambées de maladies</term>
<term>Homme</term>
<term>Humains</term>
<term>Macaca fascicularis</term>
<term>Modèles animaux de maladie humaine</term>
<term>Santé mondiale</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
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<front><div type="abstract" xml:lang="en">Background The worldwide outbreak of severe acute respiratory syndrome (SARS) is associated with a newly discovered coronavirus, SARS-associated coronavirus (SARS-CoV). We did clinical and experimental studies to assess the role of this virus in the cause of SARS. Methods We tested clinical and postmortem samples from 436 SARS patients in six countries for infection with SARS-CoV, human metapneumovirus, and other respiratory pathogens. We infected four cynomolgus macaques (Macaca fascicularis) with SARS-CoV in an attempt to replicate SARS and did necropsies on day 6 after infection. Findings SARS-CoV infection was diagnosed in 329 (75%) of 436 patients fitting the case definition of SARS; human metapneumovirus was diagnosed in 41 (12%) of 335, and other respiratory pathogens were diagnosed only sporadically. SARS-CoV was, therefore, the most likely causal agent of SARS. The four SARS-CoV-infected macaques excreted SARS-CoV from nose, mouth, and pharynx from 2 days after infection. Three of four macaques developed diffuse alveolar damage, similar to that in SARS patients, and characterised by epithelial necrosis, serosanguineous exudate, formation of hyaline membranes, type 2 pneumocyte hyperplasia, and the presence of syncytia. SARS-CoV was detected in pneumonic areas by virus isolation and RT-PCR, and was localised to alveolar epithelial cells and syncytia by immunohistochemistry and transmission electron microscopy. Interpretation Replication in SARS-CoV-infected macaques of pneumonia similar to that in human beings with SARS, combined with the high prevalence of SARS-CoV infection in SARS patients, fulfill the criteria required to prove that SARS-CoV is the primary cause of SARS.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>France</li>
<li>Hong Kong</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>République populaire de Chine</li>
<li>Singapour</li>
<li>Suisse</li>
</country>
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<name sortKey="Laman, Jon D" sort="Laman, Jon D" uniqKey="Laman J" first="Jon D." last="Laman">Jon D. Laman</name>
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<name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name>
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<name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name>
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<name sortKey="Van Riel, Debby" sort="Van Riel, Debby" uniqKey="Van Riel D" first="Debby" last="Van Riel">Debby Van Riel</name>
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<country name="République populaire de Chine"><noRegion><name sortKey="Lim, Wilina" sort="Lim, Wilina" uniqKey="Lim W" first="Wilina" last="Lim">Wilina Lim</name>
</noRegion>
</country>
<country name="Singapour"><noRegion><name sortKey="Ai Ee Ling" sort="Ai Ee Ling" uniqKey="Ai Ee Ling" last="Ai Ee Ling">AI EE LING</name>
</noRegion>
</country>
<country name="Hong Kong"><noRegion><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name>
</noRegion>
<name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name>
<name sortKey="Tam, John S" sort="Tam, John S" uniqKey="Tam J" first="John S." last="Tam">John S. Tam</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Zambon, Maria C" sort="Zambon, Maria C" uniqKey="Zambon M" first="Maria C." last="Zambon">Maria C. Zambon</name>
</region>
<name sortKey="Gopal, Robin" sort="Gopal, Robin" uniqKey="Gopal R" first="Robin" last="Gopal">Robin Gopal</name>
</country>
<country name="Allemagne"><region name="Hambourg"><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
</region>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
</region>
<name sortKey="Escriou, Nicolas" sort="Escriou, Nicolas" uniqKey="Escriou N" first="Nicolas" last="Escriou">Nicolas Escriou</name>
<name sortKey="Manuguerra, Jean Claude" sort="Manuguerra, Jean Claude" uniqKey="Manuguerra J" first="Jean-Claude" last="Manuguerra">Jean-Claude Manuguerra</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Stohr, Klaus" sort="Stohr, Klaus" uniqKey="Stohr K" first="Klaus" last="Stöhr">Klaus Stöhr</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000401 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000401 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Pascal:03-0484722
   |texte=   Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

Serveur d'exploration SRAS

Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome

Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.